![]() ![]() These results are discussed in the context of dopaminergic and serotonergic signaling. The suggestion that E 2 may improve acquisition on tasks dependent on the hippocampus will require further validation. Overall, the findings indicate that E 2 compromises performance on prefrontally-mediated tasks. No effect of treatment was detected for Detour Reaching or affiliative behaviours. Performance acquisition on the DMP tended to be better in E 2-treated relative to control monkeys, but the group difference did not reach statistical significance. Their performance also tended to be worse than that of control monkeys on the Delayed Response task. E 2-treated monkeys were significantly impaired on the second Reversal and showed an increase in perseverative responding from Reversals 1 to 3. Acquisition of a delayed matching-to-position task with a 1s delay was also administered following completion of these tests. ![]() ![]() Adult monkeys (3-5 years of age) were trained to a specific learning criterion on a battery of cognitive tasks preoperatively (object discrimination, delayed response with increasing delays and detour reaching with opaque box) and tested on different versions of these tasks (object reversals, delayed response with randomised delays and detour reaching with clear box) following ovariectomy and simultaneous implantation with 17β-oestradiol (E 2, n=6) or blank (n=6) Silastic capsules. We present the first study examining the effects of oestrogens on cognitive function in female marmosets. The common marmoset ( Callithrix jacchus) provides many advantages over traditional rodent and macaque species as a model for human aging and may be very valuable to study the effects of sex steroids on cognitive and brain aging. ![]()
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